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IMMUNOGLOBULIN JOINING REGION
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DeCS
Descriptor
English
:
Immunoglobulin Joining Region
Descriptor
Spanish
:
Región de Unión de la Inmunoglobulina
Descriptor
Portuguese
:
Região de Junção de Imunoglobulinas
Synonyms
English
:
Ig Joining Region
Immunoglobulin Joining Region Peptide Fragments
Joining Region, Ig
Joining Region, Immunoglobulin
Tree Number:
D12.644.541.500.650.500.590
D12.776.124.486.485.680.650.500.590
D12.776.124.486.485.797.590
D12.776.124.790.651.680.650.500.590
D12.776.124.790.651.797.590
D12.776.377.715.548.680.650.500.590
D12.776.377.715.548.797.590
Definition
English
:
A segment of the
immunoglobulin heavy chains
, encoded by the IMMUNOGLOBULIN HEAVY CHAIN GENES in the J segment where, during the maturation of
B-LYMPHOCYTES
; the gene segment for the variable region
upstream
is joined to a constant region gene segment
downstream
. The exact position of joining of the two gene segments is variable and contributes to
ANTIBODY DIVERSITY
. It is distinguished from the IMMUNOGLOBULIN J CHAINS; a separate polypeptide that serves as a linkage piece in polymeric IGA or IGM.
Pharmacological Action:
Immunologic Factors
See Related
English
:
Genes, Immunoglobulin
History Note
English
:
88
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CH
chemistry
CL
classification
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22919
Unique Identifier:
D007133
Occurrence in VHL
:
Similar:
DeCS